Plinest, Nucleofill and Vitaran · Under-eye specialists
Polynucleotides in Cardiff
Regenerative skin treatment that supports the skin’s own repair, popular for tired, crepey skin under the eyes, delivered by our nurse prescriber in a regulated medical clinic.
At a glance
Price
From £140, course prices available
Treatment time
About 30 minutes
Popular for
Under-eyes, face and neck
Recovery
Small bumps or redness for a day or two
Course
Usually 3 sessions, 2 to 4 weeks apart
Results
Build gradually over the course
Maintenance
Typically every 6 to 12 months
Rated excellent on Google
By our patients
HIW registered
Healthcare Inspectorate Wales
Nurse prescriber-led
Registered nurse & independent prescriber
Award-winning clinic
Best Cosmetic Surgery Clinic 2026
What are polynucleotides?
Polynucleotides are purified fragments of DNA, usually from salmon or trout, injected into the skin. They support the skin’s natural repair processes, gradually improving firmness, texture, hydration and fine lines. They improve skin quality rather than adding volume.
They are especially popular for the under-eye area, where the skin is thin and fillers are not always suitable. At Excel Clinic we offer Plinest, Plinest Eye, Plinest Newest, Nucleofill and Vitaran.
Medically reviewed by Kelsie Arandjelovic, RN, Independent Prescriber (NMC PIN 23B0374W, check the NMC register). Last updated November 2026.
What polynucleotides can help with
Under-eyes
Thin, crepey or tired-looking skin and fine lines under the eyes.
Fine lines
Early lines and loss of firmness across the face.
Texture
Dull or uneven skin texture and tone.
Neck
Crepey skin and early laxity on the neck.
Skin booster or polynucleotides?
Both improve skin quality without changing your features, but they work differently.
Skin boosters
Mainly hydrate the skin with hyaluronic acid. Results show sooner and suit dryness, dullness and early laxity.
Polynucleotides
Work on the skin’s own repair processes, so results build more gradually. Particularly good for thin, delicate skin such as under the eyes.
Not sure?
Many patients benefit from either, and some from a combination. Kelsie will recommend what suits your skin at your consultation.
Is it right for me?
Polynucleotides may suit you if…
- Your under-eyes look tired, thin or crepey
- You want gradual, natural improvement in skin quality
- You don’t want to change your features
Not suitable if…
- You have a fish allergy, or avoid animal-derived products
- You are pregnant or breastfeeding
- You have an active skin infection in the area
- You are under 18
Polynucleotide prices
Single sessions and better-value courses of three.
Why a medical clinic matters
Aesthetics, backed by a medical and surgical clinic
Excel Clinic is an award-winning private medical and surgical clinic, registered with Healthcare Inspectorate Wales. Your aesthetic treatment benefits from the same clinical standards, safety systems and team of doctors and consultant surgeons as everything else we do, so you can relax and enjoy your results with complete peace of mind.
A regulated medical clinic
Excel Clinic is registered with and inspected by Healthcare Inspectorate Wales. The same clinical governance, infection control and record-keeping that apply to our surgical work apply to every aesthetic treatment.
Doctors and surgeons on site
Aesthetics sits alongside our surgical, skin and medical services, delivered by doctors and consultant surgeons. Our practitioner works within a wider clinical team, not on her own.
Assessed, prescribed and treated by one person
Kelsie is an independent prescriber, so she can assess you, prescribe where needed and treat you herself. Remote prescribing for cosmetic injectables is not permitted in the UK, and we never rely on it.
Complications managed in-house
If anything doesn’t go to plan, you won’t be told to see your GP. Kelsie can assess and treat complications herself, filler can be dissolved on site, and the clinic has medical emergency protocols and equipment.
Clinical treatment rooms
Treatments take place in clinical rooms in a purpose-fitted medical clinic, designed and cleaned to the standards needed for minor surgery.
Professional accountability
Registered healthcare professionals, full medical records, clinical insurance and a formal complaints procedure. You know exactly who is responsible for your care, and how to check their registration.
Alongside our cosmetic surgery service
Our aesthetics service works alongside our cosmetic surgery service, so if a non-surgical treatment isn’t the right answer for you, our consultant surgeons are under the same roof. That might mean lip lift surgery for a long upper lip, or eyelid surgery for heavy or hooded eyelids. There’s no pressure either way: our aim is simply to recommend the treatment that’s right for you.
What happens, step by step
Send your form
Tell us which area you’d like to improve and we’ll call you back.
Consultation
Skin assessment, medical history and the right product and course.
Treatment
Small, precise injections, taking about 30 minutes.
Your course
Usually three sessions two to four weeks apart, then maintenance.
Your practitioner
One practitioner, from consultation to review
Kelsie Arandjelovic
Aesthetic Nurse Prescriber · RN, Independent Prescriber · PgCert Cosmetic & Aesthetic Medicine
Every aesthetic treatment at Excel Clinic is planned and carried out by Kelsie, a registered nurse and independent prescriber with four years’ experience in medical aesthetics. She is a member of the Aesthetic Complications Expert (ACE) Group and the Royal College of Nursing.
Kelsie’s background in NHS community nursing shapes how she works: thorough assessment, patient safety first, and an honest answer if a treatment isn’t right for you. She has a special interest in facial profile balancing.
Risks and side effects
- Expected: small bumps, redness or mild swelling at injection points, settling within a day or two.
- Common: bruising, particularly under the eyes.
- Uncommon: a reaction to the product. Polynucleotides are fish-derived, so they are not suitable if you have a fish allergy.
- Rare: infection. Kelsie can assess and treat complications herself, in a clinic with medical emergency equipment on site.
Aftercare
First 24 hours
- Don’t touch or massage the treated area
- No make-up for 12 hours
- Avoid alcohol, strenuous exercise, saunas and extreme temperatures
First week
- Gentle skincare only for 48 hours
- Avoid retinol and exfoliating acids for 3 to 5 days
- Protect the area from strong sun; no sunbeds
Your course
- Keep to your session schedule for the best result
- Improvement builds progressively over the course
Why patients choose Excel Clinic
Nurse prescriber-led
Every treatment is planned and carried out by Kelsie Arandjelovic, a registered nurse and independent prescriber.
Regulated medical clinic
Registered with Healthcare Inspectorate Wales, with doctors and consultant surgeons on site.
Award-winning and highly rated
Best Cosmetic Surgery Clinic 2026 and rated excellent on Google by our patients.
Honest, no-pressure advice
A face-to-face consultation first, and a straight answer if treatment isn’t right for you.
What our patients say
Frequently asked questions
What are polynucleotides?
Purified DNA fragments, usually from salmon or trout, injected into the skin to support its natural repair. They improve skin quality rather than adding volume.
Are polynucleotides good for under the eyes?
They are a popular option for thin, crepey or tired-looking skin under the eyes. Plinest Eye and Vitaran Eyes are designed for this area.
How much do polynucleotides cost in Cardiff?
At Excel Clinic, from £140 per session, or from £380 for a course of three.
How many sessions will I need?
Usually a course of three, two to four weeks apart, with maintenance sessions afterwards.
When will I see results?
Improvement builds gradually over the course, with skin quality continuing to improve for several weeks after your last session.
Are polynucleotides suitable for vegans?
No. They are fish-derived, so they are not suitable if you avoid animal products or have a fish allergy.
Do I need a consultation first?
Yes. Every treatment starts with a face-to-face consultation with Kelsie, who reviews your medical history and skin and recommends the right product and course. The £50 fee is redeemable against treatment.
Is there an age limit?
We only treat adults aged 18 and over.
Where is the clinic?
Excel Clinic is at 3 Oaktree Court, Mulberry Drive, Cardiff Gate Business Park, Cardiff CF23 8RS, a couple of minutes from Junction 30 of the M4.
Find us
Excel Clinic
3 Oaktree Court, Mulberry Drive
Cardiff Gate Business Park
Cardiff CF23 8RS
Monday to Friday, 9am to 5pm
02922 645305
A couple of minutes from Junction 30 of the M4. We see aesthetics patients from Pontprennau, Lisvane, Llanishen, Cyncoed, Roath, Cardiff city centre, Cardiff Bay, Penarth, Caerphilly, Newport, Cwmbran and the Vale of Glamorgan.
Ready to talk to us?
Send a short form and we’ll be in touch to arrange your consultation with Kelsie.
Book a polynucleotide consultation
Tell us which area you’d like to improve. We’ll call you back to arrange your consultation.
More aesthetic treatments: Aesthetics · Lines and wrinkles · Dermal filler · Profile balancing · Filler dissolving · Skin boosters · Microneedling · Price list